Preclinical evaluation of nephroprotective potential of a probiotic formulation LOBUN on Cyclosporine-A induced renal dysfunction in Wistar rats

ABSTRACT The aim of present study was to evaluate the nephroprotective effect of probiotic formulation LOBUN on Cyclosporine A (CsA) induced renal dysfunction in Wistar rats. CsA (20 mg/kg body weight s.c) was administered for 15 days to cause renal dysfunction in Wistar rats. The probiotic formulation LOBUN was administered with the dose of 500 mg/kg body weight (p.o) for twice (TGI) and thrice a day (TGII). The samples were analyzed for the parameters like blood urine nitrogen (BUN), serum creatinine, serum uric acid, total serum protein and urine proteins, urine potassium, urine sodium. The renal functional and histopathological studies revealed that the oral administration of probiotic formulation LOBUN has provided appreciable renoprotection and possibly alleviated the symptoms of Chronic Kidney Disease (CKD) at the dose of 500 mg/kg body weight administered thrice a day and also the results were supported by histopathological findings.

Soporte nutricional en el niño con enfermedad de injerto contra huésped / Nutritional support in children with graft versus host disease

La enfermedad injerto contra huésped, generalmente ocurre luego del trasplante de médula ósea alogénico.Puede ser aguda, en dos fases, aferente y eferente; y crónica, que semeja una enfermedad autoinmune. Lasmanifestaciones clínicas más frecuentes son enterocólicas. La prevención es la clave del tratamiento. Su evolución depende de la severidad de las lesiones. El soporte nutricional comprende el aporte adecuado deenergía, macro y micronutrimentos y la interacción fármaco nutrimento. Los beneficios de la inmunonutrición incluyen la disminución del riesgo de infección, el menor tiempo de estancia hospitalaria, y en cuidados intensivos.

Graft versus host disease, usually occurs after bone marrow trasnplantation, allgeneic. It may be acute, intwo phases, afferent and efferent, and chronic, which resembles an autoinmune disease. The most frequentclinical manifestations are enterocolic. Prevention is the key to treatment. Its evolution depends on the severity of injuries. Nutritional support includes adequate intake of energy, macro and micronutrients and nutrient drug interaction. Immunonutrition benefits include reduced risk of infecion, shorter hospital stay, and intensive care.